Dental infections and serum inflammatory markers in patients with and without severe heart disease
Identifieur interne : 002180 ( Main/Exploration ); précédent : 002179; suivant : 002181Dental infections and serum inflammatory markers in patients with and without severe heart disease
Auteurs : Jukka H. Meurman [Finlande, États-Unis] ; Sok-Ja Janket ; Markku Qvamström ; Pekka NuutinenSource :
- Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [ 1079-2104 ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Objective. The objective of this study was to investigate if patients with severe heart disease (CHD patients) present more signs of dental infections than patients without heart disease (non-CHD patients), if serum inflammatory markers differ between the groups, and if there is a link between these and the oral health parameters. Methods. We performed clinical and radiologic dental examinations and collected serum samples of 256 patients with New York Heart Association class II-IV heart disease (CHD patients) and 250 non-CHD controls. Serum samples were analysed using pertinent methods in the clinical laboratory of the hospital, and the differences in serum biomarkers between CHD patients and non-CHD patients were examined using various statistical methods. A modified dental index (MDI) was constructed and used in the analyses. Results. CHD patients were significantly more likely to be edentulous (34.8% vs. 14.8%) and retain less natural teeth than non-CHD patients (8.6 vs. 17) (P <.001). In CHD patients the remaining teeth and supporting tissues were more often diseased. High MDI scores were significantly associated with CHD status (OR 1.31, Cl 1.16-1.48), as was gingivitis (OR 3.37, Cl 1.66-6.86), while the presence of deep periodontal pockets was not. Serum C-reactive protein and fibrinogen concentrations and blood erythrocyte sedimentation rates were higher in the CHD group. Also, H. pylori and Chlamydia antibodies were significantly higher in the CHD group. Conclusion. CHD patients presented with poorer oral health status than non-CHD patients. Serum inflammatory markers were significantly higher in the CHD patients compared to the non-CHD group. High MDI scores linked with risk of CHD.
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Meurman</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>University of Helsinki, Helsinki University Central Hospital</s1><s3>FIN</s3></inist:fA14><country>Finlande</country><wicri:noRegion>University of Helsinki, Helsinki University Central Hospital</wicri:noRegion><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Harvard School of Public Health</s1><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Harvard School of Public Health</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Kuopio University Hospital</s1><s3>FIN</s3></inist:fA14><country>Finlande</country><wicri:noRegion>Kuopio University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Janket, Sok Ja" sort="Janket, Sok Ja" uniqKey="Janket S" first="Sok-Ja" last="Janket">Sok-Ja Janket</name></author><author><name sortKey="Qvamstrom, Markku" sort="Qvamstrom, Markku" uniqKey="Qvamstrom M" first="Markku" last="Qvamström">Markku Qvamström</name></author><author><name sortKey="Nuutinen, Pekka" sort="Nuutinen, Pekka" uniqKey="Nuutinen P" first="Pekka" last="Nuutinen">Pekka Nuutinen</name></author></analytic><series><title level="j" type="main">Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics</title><title level="j" type="abbreviated">Oral surg. oral med. oral pathol. oral radiol. endo.</title><idno type="ISSN">1079-2104</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics</title><title level="j" type="abbreviated">Oral surg. oral med. oral pathol. oral radiol. endo.</title><idno type="ISSN">1079-2104</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological marker</term><term>Heart disease</term><term>Human</term><term>Infection</term><term>Serum</term><term>Severe</term><term>Tooth</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Infection</term><term>Cardiopathie</term><term>Dent</term><term>Sérum</term><term>Marqueur biologique</term><term>Homme</term><term>Grave</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective. The objective of this study was to investigate if patients with severe heart disease (CHD patients) present more signs of dental infections than patients without heart disease (non-CHD patients), if serum inflammatory markers differ between the groups, and if there is a link between these and the oral health parameters. Methods. We performed clinical and radiologic dental examinations and collected serum samples of 256 patients with New York Heart Association class II-IV heart disease (CHD patients) and 250 non-CHD controls. Serum samples were analysed using pertinent methods in the clinical laboratory of the hospital, and the differences in serum biomarkers between CHD patients and non-CHD patients were examined using various statistical methods. A modified dental index (MDI) was constructed and used in the analyses. Results. CHD patients were significantly more likely to be edentulous (34.8% vs. 14.8%) and retain less natural teeth than non-CHD patients (8.6 vs. 17) (P <.001). In CHD patients the remaining teeth and supporting tissues were more often diseased. High MDI scores were significantly associated with CHD status (OR 1.31, Cl 1.16-1.48), as was gingivitis (OR 3.37, Cl 1.66-6.86), while the presence of deep periodontal pockets was not. Serum C-reactive protein and fibrinogen concentrations and blood erythrocyte sedimentation rates were higher in the CHD group. Also, H. pylori and Chlamydia antibodies were significantly higher in the CHD group. Conclusion. CHD patients presented with poorer oral health status than non-CHD patients. Serum inflammatory markers were significantly higher in the CHD patients compared to the non-CHD group. High MDI scores linked with risk of CHD.</div></front></TEI><affiliations><list><country><li>Finlande</li><li>États-Unis</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Janket, Sok Ja" sort="Janket, Sok Ja" uniqKey="Janket S" first="Sok-Ja" last="Janket">Sok-Ja Janket</name><name sortKey="Nuutinen, Pekka" sort="Nuutinen, Pekka" uniqKey="Nuutinen P" first="Pekka" last="Nuutinen">Pekka Nuutinen</name><name sortKey="Qvamstrom, Markku" sort="Qvamstrom, Markku" uniqKey="Qvamstrom M" first="Markku" last="Qvamström">Markku Qvamström</name></noCountry><country name="Finlande"><region name="Uusimaa"><name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name></region><name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name></country><country name="États-Unis"><noRegion><name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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